Journals
18th UICC International Cancer Congress
Demidov LV, Manziuk LV, Kharkevitch GY, Artamonova EV, Pirogova NA (2002): Antimetastatic effect of Avemar in high-risk melanoma patients. 18th UICC International Cancer Congress.
2nd Congress of the World Society for Breast Health
Tompa A, Kocsis Z, Marcsek Z, Jakab M, Szende B, Hidvégi M (2003): Chemoprevention with Tamoxifen and Avemar by inducing apoptosis on MCF-7 (ER+) Breast cancer cells. In: 2nd Congress of the World Society for Breast Health. Monduzzi Editore, Bologna, p. 61-6.
Acta Microbiologica et Immunologica Hungarica
Kövesdi V, Stercz B, Tompa A, Ongradi J (2009): Effect of fermented wheat germ extract on feline viruses (a pilot study). Acta Microbiologica et Immunologica Hungarica.
Acta Microbiologica et Immunologica Hungarica
Hajtó T, Adámy A, Langmár Z, Kirsch A, Ábrahám L, Perjési P, Németh P (2013): Enhanced effectiveness of conventional oncotherapy with plant immunomodulators: Overview of recent advances. Advancement Medicinal Plant Res. 1(3):56-65.
African Journal of Biological Sciences
Barakat H, Khalil FA, Khalifa FK, Hessin MM (2011): Biochemical role of fermented wheat germ on liver and kidney functions alteration induced by chlorpyrifos in rats. Afr J Biol Sci. 7(1):45-60.
African Journal of Biomedical Research
Yusuf OK, Bewaji CO, Ekanem JT (2010): Biochemical evaluation of fermented wheat germ extract on Trypanosoma brucei-infected rats. Afr J Biomed Res. 13:219-24.
African Journal of Biomedical Research
Buta S, Al-Ibrahim AS (2021): Enriching Arabic bread wheat germ fermented by baker’s yeast. Al-Baath University Journal. 43(6): 45-64, 2021.
African Journal of Biomedical Research
Ellakany H, El-Sayed AE-H, Soliman F, Elbestawy A (2017): The effect of fermented wheat germ extract on biochemical, physiological and performance parameters of broiler chickens. Alexandria Journal of Veterinary Sciences. 55(2): 91-7.
Alternative and Integrative Medicine
Hajtó T, Adámy A, Baranyai L, Langmár Z, Kirsch A, Kuzma M, Ábrahám L, Perjési P (2014): Can standardized plant extracts induce complete remission in patients with metastatic tumors? Altern Integ Med. 3(3):161.
Alternative Therapies
Johanning GL, Wang-Johanning F (2007): Efficacy of a medical nutriment in the treatment of cancer. Altern Ther Health Med. 13(2):56-65.
Alternatives for the Health Conscious individual
Williams DG (2005): A cancer therapy out of the blue. Alternatives for the Health Conscious Individual. 11(3):17-24.
Annals of the New York Academy of Sciences
Boros LG, Nichelatti M, Shoenfeld Y, Shoenfeld Y (2005): Fermented wheat germ extract (Avemar) in the treatment of cancer and autoimmune diseases. Ann N Y Acad Sci. 1051:529-42.
Telekes A, Kiss-Tóth E, Nagy T, Qwarnstrom EE, Kúsz E, Polgár T, Resetár Á, Dower SK, Duda E (2005): Synergistic effect of Avemar on proinflammatory cytokine production and Ras-mediated cell activation. Ann N Y Acad Sci. 1051:515–28.
Telekes A, Resetár Á, Bálint G, Blazsó G, Falkay G, Lapis K, Rásó E, Szende B, Ehrenfeld M, Shoenfeld Y, Hidvégi M (2007): Fermented wheat germ extract (Avemar) inhibits adjuvant arthritis. Ann N Y Acad Sci. 1110:348-61.
Anti-aging medical news
Pelletier M (2008): Unplugging cancer’s power supply. Anti-Aging Medical News. Summer issue:188-90.
Anticancer Research
Hidvégi M, Rásó E, Tömösközi-Farkas R, Paku S, Lapis K, Szende B (1998): Effect of Avemar and Avemar + Vitamin C on tumor growth and metastasis in experimental animals. Anticancer Res. 18:2353-8.
Ápolásügy
Horváth J, Olajos J (2020): Klinikai táplálásterápia az onkológiában. Ápolásügy. 34(3), 15-16. 2020.
Autoimmunity Reviews
Sukkar SG, Rossi E (2004): Oxidative stress and nutritional prevention in autoimmune rheumatic diseases. Autoimmunity Reviews. 3(2004):199–206.
Biomedical and Environmental Sciences
Zhang J, Xiao X, Dong Y, Wu J, Zhou X (2015): Antitumor activities and apoptosis-regulated mechanisms of fermented wheat germ extract in the transplantation tumor model of human HT-29 cells in nude mice. Biomed Environ Sci. 28(10): 718-27.
BioMedicine
Liu J-C, Shen W-C, Shih T-C, Tsai C-W, Chang W-S, Cho D-Y, Tsai C-H, Bau D-T (2015): The current progress and future prospects of personalized radiogenomic cancer study. BioMedicine. Vol. 5, No. 1, Article 2, Pages 11-18.
Biometrical Letters
Sawikowska A (2020): Meta-analysis of flavonoids with antiviral potential against coronavirus. Biometrical Letters. doi:10.2478/bile-2020-0002
BMC Complementary and Alternative Medicine
Otto C, Hahlbrock T, Eich KPJ, Karaaslan F, Jürgens C, Germer C-T, Wiegering A, Kämmerer U (2016): Antiproliferative and antimetabolic effects behind the anticancer property of fermented wheat germ extract. BMC Complement Altern Med. 16:160 (10 pages). doi:10.1186/s12906-016-1138-5
Breast Cancer
Pole L, Hepp N, Lerner M (2018): Beyond Conventional Cancer Therapies. Breast Cancer. Available at: https://bcct.ngo/assets/documents/BreastCancer12-10-18.pdf
British Journal of Cancer
Jakab F, Shoenfeld Y, Balogh Á, Nichelatti M, Hoffmann A, Kahán Z, Lapis K, Mayer Á, Sápy P, Szetntpétery F, Telekes A, Thurzó L, Vágvölgyi A, Hidvégi M (2003): A medical nutriment has supportive value in the treatment of colorectal cancer. Br J Cancer. 89(3):465-9.
Langbein S, Zerilli M, Hausen A, Staiger W, Rensch-Boschert K, Lukan N, Popa J, Ternullo MP, Steidler A, Weiss C, Grobholz R, Willeke F, Alken P, Stassi G, Schubert P, Coy JF (2006): Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted. Br J Cancer. 94:578-85.
Cancer & Metabolism
Klein P, Tyrlikova I, Zuccoli G, Tyrlik A, Maroon JC (2020): Treatment of glioblastoma multiforme with “classic” 4:1 ketogenic diet total meal replacement. Cancer Metab. 8, 24. doi:https://doi.org/10.1186/s40170-020-00230-9
Cancer Biotherapy & Radiopharmaceuticals
Hidvégi M, Rásó E, Tömösközi-Farkas R, Szende B, Paku S, Prónai L, Bocsi J, Lapis K (1999): MSC, a new benzoquinone-containing natural product with antimetastatic effect. Cancer Biother Radiopharm. 14(4):277-89.
Szende B, Marcsek Z, Kocsis Z, Tompa A (2004): Effect of simultaneous administration of Avemar and cytostatic drugs on viability of cell cultures, growth of experimental tumors, and survival of tumor-bearing mice. Cancer Biother Radiopharm. 19(3):343-9.
Marcsek Z, Kocsis Z, Jakab M, Szende B, Tompa A (2004): The efficacy of tamoxifen in estrogen receptor–positive breast cancer cells is enhanced by a medical nutriment. Cancer Biother Radiopharm. 19(6):746-53.
Demidov LV, Manziuk LV, Kharkevitch GY, Pirogova NA, Artamonova EV (2008): Adjuvant fermented wheat germ extract (Avemar) nutraceutical improves survival of high-risk skin melanoma patients: a randomized, pilot, phase II clinical study with a 7-year follow-up. Cancer Biother Radiopharm. 23(4):477-82.
Cancer Control
Myers C, Stuber ML, Bonamer-Rheingans JI, Zeltzer LK (2005): Complementary therapies and childhood cancer. Cancer Control. 12(3):172-80.
Cancer Letters
Saiko P, Ozsvar-Kozma M, Madlener S, Bernhaus A, Lackner A, Grusch M, Horváth Z, Krupitza G, Jaeger W, Ammer K, Fritzer-Szekeres M, Szekeres T (2006): Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells. Cancer Lett. 250:323-8.
Cancers
Harguindey S, Reshkin SJ, Alfarouk KO (2023): The prime and integral cause of cancer in the post-Warburg era. Cancers. 2023, 15(2), 540. doi:https://doi.org/10.3390/cancers15020540
Carcinogenesis
Zalatnai A, Lapis K, Szende B, Rásó E, Telekes A, Resetár Á, Hidvégi M (2001): Wheat germ extract inhibits experimental colon carcinogenesis in F-344 rats. Carcinogenesis. 22(10):1649-52.
Chromatographia
Tömösközi-Farkas R, Daood HG (2004): Modification of chromatographic method for the determination of benzoquinones in cereal products. Chromatographia. 12:227-30.
Clinical and Experimental Rheumatology
Bálint G, Apáthy Á, Gaál M, Telekes A, Resetár Á, Blazsó G, Falkay G, Szende B, Paksy A, Ehrenfeld M, Shoenfeld Y, Hidvégi M (2006): Effect of Avemar – a fermented wheat germ extract – on rheumatoid arthritis. Preliminary data. Clin Exp Rheumatol. 24:325-8.
Clinical Laboratory
Coy JF, Dressler D, Wilde J, Schubert P (2005): Mutations in the Transketolase-like gene TKTL1: Clinical implications for neurodegenerative diseases, diabetes and cancer. Clin Lab. 51:257-73.
Colloids and Surfaces A
Hung H-S, Bau D-T, Yeh C-A, Kung M-L (2019): Evaluation of cellular uptake mechanisms for AuNP-collagen-Avemar nanocarrier on transformed and non-transformed cell lines. Colloids and Surfaces A. (2019) 580:123791.
Complement Therapies
Challem J (2012): Fermented wheat germ extract – An adjunct treatment for cancer? Alternat Complement Therapies. 18(4):199-201.
Complementary and Alternative Medicine Guide
Ehrlich SD (2012): Bone cancer. University of Maryland Medical Center. Complementary and Alternative Medicine Guide. Baltimore, MD.
Comprehensive Reviews in Food Science and Food Safety
Gan R-Y, Li H-B, Gunaratne A, Sui Z-Q, Corke H (2017): Effects of fermented edible seeds and their products on human health: Bioactive components and bioactivities. Comprehensive Reviews in Food Science and Food Safety. doi:10.1111/1541-4337.12257
Critical Reviews in Oncology/Hematology
Mishra J, Dromund J, Quazi SH, Karanki SS, Shaw JJ, Chen B, Kumar N (2013): Prospective of colon cancer treatments and scope for combinatorial approach to enhanced cancer cell apoptosis. Crit Rev Oncol Hematol. 86(3): 232-50.
Current Cancer Drug Targets
Boros LG, Brackett DJ, Harrigan GG (2003): Metabolic biomarker and kinase drug target discovery in cancer using stable isotope-based dynamic metabolic profiling (SIDMAP). Current Cancer Drug Targets. 3:447-55.
Current Opinion in Pharmacology
Khanna D, Sethi G, Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal A, Aggarwal BB (2007): Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol. 7:344–51.
Drug Discovery Today
Boros LG, Cascante M, Lee W-NP (2002): Metabolic profiling of cell growth and death in cancer: applications in drug discovery. Drug Discovery Today. 7(6):18-26.
European Food Research and Technology
Rizzello CG, Nionelli L, Coda R, Di Cagno R, Gobbetti M (2010): Use of sourdough fermented wheat germ for enhancing the nutritional, texture and sensory characteristics of the white bread. Eur Food Res Technol. 230:645–54.
European Journal of Cancer Supplements
Voigt W, Mueller T, Jordan K, Reipisch F, Nerger K, Schmoll HJ (2009): Promising cytotoxic activity profile of fermented wheat germ extract (Avemar) in human cancer cell lines . Eur J Cancer. S7:110.
Evidence-based Complementary and Alternative Medicine 8
Iyer A, Brown L (2009): Fermented wheat germ extract (Avemar) in the treatment of cardiac remodeling and metabolic symptoms in rats. Evid Based Complement Alternat Med. 2011:508957.
Tai C-J, Wang W-C, Wang C-K, Wu C-H, Yang M-D, Chang Y-J, Jian J-Y, Tai C-J (2013): Fermented wheat germ extract (FWGE) induced cell death and enhanced cytotoxicity of cisplatin and 5-fluorouracil on human hepatocellular carcinoma cells. Evid-based Compl Altern Med. Vol. 2013, Article ID 121725, 9 pages.
Wang C-W, Wang C-K, Chang Y-J, Choong C-Y, Lin C-S, Tai C-J, Tai C-J (2015): Preclinical evaluation on the tumor suppression efficiency and combination drug effects of fermented wheat germ extract in human ovarian carcinoma cells. Evid-based Compl Altern Med. Vol. 2015, Article ID 570785, 8 pages.
Lai JN, Chen PC, Wang JD, Wu TCJ, Chung V (2015): Integrative gynecology and women’s healthcare. Evid-based Compl Altern Med. Article ID 852615.
Experimental Biology and Medicine
Illmer C, Madlener S, Horváth Z, Saiko P, Losert A, Herbacek I, Grusch M, Krupitza G, Fritzer-Szekeres M, Szekeres T (2005): Immunologic and biochemical effects of the fermented wheat germ extract Avemar. Exp Biol Med. (Maywood). 230:144-9.
Experimental Biology and Medicine
Tereshina NS, Samylina IA, Kostennikova ZP (2012): Drug fermentation and preparation. Farmaciya. 2012(3): 53-6.
Food Chemistry
Rizzello CG, Nionelli L, Coda R, De Angelis M, Gobbetti M (2010): Effect of sourdough fermentation on stabilisation, and chemical and nutritional characteristics of wheat germ. Food Chemistry. 119(2010):1079-89.
Rizzello CG, Cassone A, Coda R, Gobbetti M (2011): Antifungal activity of sourdough fermented wheat germ used as an ingredient for bread making. Food Chemistry. 127:952-9.
Food Engineering Progress
Yoo J-G, Kim M-D (2010): Production of 2-Methoxy-1,4-benzoquinone (2-MBQ) and 2,6-Dimethoxy-1,4-benzoquinone (2,6-DMBQ) from wheat germ using lactic acid bacteria and yeast. Food Engineering Progress. 14(4):292-8.
Food Sci Biotechnol
Liaqat H, Jeong E, Kim KJ, Kim JY (2020): Effect of wheat germ on metabolic markers: a systematic review and meta-analysis of randomized controlled trials. Food Sci Biotechnol. 29(6):739-49.
Food Sci Technol
Jing X, Dong Y (2009): Study on 2,6-DMBQ from fermented wheat germ. Food Sci Technol (Chinese). 2009-06.
Kesika P, Sivamaruthi BS, Chaiyasut C (2020): Health promoting effects of fermented foods against cancer: an updated concise review. Food Sci. Technol, Campinas. (9 pages). doi:https://doi.org/10.1590/fst.18220
Food Science and Biotechnology
Song J-H, Kim J-K, Jang H-D (2014): Ferulic acid released by treatment with Aspergillus oryzae contributes to the cellular antioxidant capacity of wheat germ extract. Food Sci Biotechnol. 23:1327-33.
Food Science and Technology
Mi S, Gu J, Cao X, Li Y, Xu Q, Chen W, Zhang Y (2022): Regulatory mechanism of fermented wheat germ on lipid metabolism in hyperlipidemia rats via activation of AMPK pathway. Food Sci Technol, Campinas. 42, e57222.
Foods
Kaur B, Kumar B, Sirhindi G, Guleria N, Kaur J (2023): Phenolic biotransformations in wheatgrass juice after primary and secondary fermentation. Foods. 12, 1624.
Frontier of Nutrition
Du K, Tian S, Chen H, Gao S, Dong X, Yan F (2022): Application of enzymes in the preparation of wheat germ polypeptides and their biological activities. Front Nutr. 9: 943950. (11 pages). doi:10.3389/fnut.2022.943950
Frontiers in Nutrition
Verni M, Rizzello CG, Coda R (2019): Fermentation Biotechnology Applied to Cereal Industry By-Products: Nutritional and Functional Insights. Front Nutr. 2019;6:42. 13 p. Published 2019 Apr 12. doi:10.3389/fnut.2019.00042
Health Quest Podcast
Lankford S (2014): Avemar for cancer support. An interview with James LaValle. Health Quest Podcast.
Health Sciences Institute
Wright KM (2005): Is it really from heaven above? The cancer miracle that leaves healthy cells healthy. HSI Health Sciences Institute. December issue. (4 pages).
Hematology/Oncology Clinics of North America
Hardy ML (2008): Dietary supplement use in cancer care: help or harm. Hematol Oncol Clin N Am. 22:581–617.
Hepato-Gastroenterology
Jakab F, Mayer Á, Hoffmann A, Hidvégi M (2000): First clinical data of a natural immunomodulator in colorectal cancer. Hepatogastroenterology. 47:393-5.
HerbClip
Milot B (2006): Treatment of cancer and autoimmune diseases with wheat germ extract. HerbClip. 050164-313. Available at: https://www.herbalgram.org/resources/herbclip/issues/bin_313/review44660/
Immunopharmacology
Hidvégi M, Rásó E, Tömösközi-Farkas R, Lapis K, Szende B (1999): Effect of MSC on the immune response of mice. Immunopharmacology. 41:183-6.
Indian Journal of Medical Research
Lubrano V, Baldi S, Napoli D, Longo V (2012): Beneficial effect of Lisosan G on cultured human microvascular endothelial cells exposed to oxidised low density lipoprotein. Indian J Med Res. 136:82-8.
Integrative Cancer Therapies
Seely D, Ennis JK, McDonell E, Zhao L (2018): Naturopathic oncology care for thoracic cancers: A practice. Integr Cancer Ther. 17(3): 793–805.
Integrative Medicine
Cassileth BR, Yeung KS, Gubili J (2007): Wheat germ extract. In: Herb-drug interactions in oncology. Cancer Center, New York NY and People’s Medical Publishing House–USA, Shelton CT, p. 694-6.
Internal Medicine News
Walsh N (2006): Avemar as supportive therapy in cancer. Internal Medicine News. 39(13):35.
International Journal of Food Sciences and Nutrition
Brandolini A, Hidalgo A (2012): Wheat germ: not only a by-product. Int J Food Sci Nutr. 63 (Suppl 1):71-4.
International Journal of Gynecological Cancer
Judson PL, Sawah EA, Marchion DC, Xiong Y, Bicaku E, Zgheib NB, Chon HS, Stickles XB, Hakam A, Wenham RM, Apte SM, Gonzalez-Bosquet J, Chen D-T, Lancaster JM (2012): Characterizing the efficacy of fermented wheat germ extract against ovarian cancer and defining the genomic basis of its activity. Int J Gynecol Cancer. 22(6):960-7.
International Journal of Molecular Sciences
Bakalova R, Lazarova D, Sumiyoshi A, Shibata S, Zhelev Z, Nikolova B, Semkova S, Vlaykova T, Aoki I, Higashi T (2023): Redox-cycling “mitocans” as effective new developments in anticancer therapy. Int J Mol Sci. 24, 8435. (23 pages).
International Journal of Oncology
Fajka-Boja R, Hidvégi M, Shoenfeld Y, Ion G, Demydenko D, Tömösközi-Farkas R, Vizler C, Telekes A, Resetár Á, Monostori É (2002): Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor T and B cell lines. Int J Oncol. 20:563-70.
International Journal of Pharmaceutical Sciences and Health Care
El-Batal AI, Omayma AR, Eman N, Effat SI (2012): Promising antitumor activity of fermented wheat germ extract in combination with selenium nanoparticles. Int J Pharm Sci Health Care. 6(2):1. (22 pages).
International Journal of Toxicology
Heimbach JT, Sebestyén G, Semjén G, Kennepohl E (2007): Safety studies regarding a standardized extract of fermented wheat germ. Int J Toxicol. 26:253-9.
J Enzyme Inhibition Med Chem
Alfarouk KO, Alhoufie STS, Hifny A, Schwartz L, Alqahtani AS, Ahmed SBM, Alqahtani AM, Alqahtani SS, Muddathir AK, Ali H, Bashir AHH, Ibrahim ME, Greco MR, Cardone RA, Harguindey S, Reshkin SJ (2021): Of mitochondrion and COVID-19. J Enzyme Inhibition Med Chem. 36:1, 1258-1267.
Journal for ImmunoTherapy of Cancer
Barisone GA, Ma Y, Abuhay MW, O’Donnell RT, Lundeberg K, Gowda S, Murphy W, Tuscano JM (2017): A protein extract from fermented wheat germ promotes NK cell-mediated lymphoma eradication in mouse xenografts. J ImmunoTherapy Cancer. 5(Suppl 2):P306.
Journal of Agricultural and Food Chemistry
Losso JN, Bawadi HA (2005): Hypoxia inducible factor pathways as targets for functional foods. J Agric Food Chem. 53:3751-68.
Journal of Alternative & Complementary Medicine
Ladas EJ (2018): Integrative Medicine in Childhood Cancer. J Altern Compl Med. 24(9-10): 910-15.
Journal of Biomedicine and Biotechnology
Kim YS, Milner JA (2011): Bioactive food components and cancer-specific metabonomic profiles. J Biomed Biotechnol. 2011:721213 (9 pages).
Journal of Biomedicine and Biotechnology
Hajtó T, Kirsch A (2013): Case reports of cancer patients with hepatic metastases treated by standardized plant immunomodulatory preparations. J Cancer Res Updates. 2(1):1-9.
Journal of Cereals and Oilseeds
Yusuf OK, Bewaji CO (2011): GC-MS of volatile components of fermented wheat germ extract. J Cereals Oilseeds. 2(3): 38-42.
Journal of Clinical Oncology
Lee SN, Park H, Lee KE (2005): Cytotoxic activities of fermented wheat germ extract on human gastric carcinoma cells by induction of apoptosis. J Clin Oncol. 23(16):4254.
Telekes A, Rásó E (2007): Changes in the kinase expression panel of K562 human leukemia after Avemar treatment. J Clin Oncol. 25(18):14143.
Tejeda M, Gaál D, Szűcs I, Telekes A (2007): Avemar inhibits the growth of mouse and human xenograft mammary carcinomas comparable to endocrine treatments. J Clin Oncol. 25(18):21132.
Journal of Clinical Pathology
Vetvicka V, Vetvickova J (2016): Comparison of immunological properties of various bioactive combinations. Part II. Int J Clin Pathol J. 2(5):00053.
Journal of Experimental and Clinical Cancer Research
Mueller T, Jordan K, Voigt W (2011): Promising cytotoxic activity profile of fermented wheat germ extract (Avemar) in human cancer cell lines. J Exp Clin Cancer Res. 30:42. (7 pages).
Zu X, Ma X, Xie X, Lu B, Laster K, Liu K, Dong Z, Kim DJ (2020): 2,6-DMBQ is a novel mTOR inhibitor that reduces gastric cancer growth in vitro and in vivo. J Exp Clin Cancer Res. 39:107 (14 pages).
Journal of Food and Dairy Sciences
Youssef MKE, El-Tellawy FM, El-Melegy NT, Mohamed MMH (2010): Immuno-effect of raw, gamma irradiated, microwave treated and fermented wheat germs in experimental rats. J Food Dairy Sci. 1(1):29-43.
Journal of Food Science and Technology
Niu L-Y, Jiang S-T, Pan L-J (2013): Preparation and evaluation of antioxidant activities of peptides obtained from defatted wheat germ by fermentation. J Food Sci Technol. 50(1):53–61.
Rajasekaran A, Kalaivani M (2013): Designer foods and their benefits: A review. J Food Sci Technol. 50(1):1-16.
Journal of Immune Based Therapies, Vaccines and Antimicrobials
Soliman MG, Ashry OM, Ahmed MAE, Abd El-Naby YH (2015): Improvement of hematopoietic and immunologic findings in sublethal gamma irradiated rats treated with bone marrow transplantation and wheat germ oil. Journal of Immune Based Therapies, Vaccines and Antimicrobials. 4: 9-18.
Journal of Medicinal Plants Research
Yusuf OK, Ekanem JT (2010): Studies of phytochemical constituents and anti-trypanosomal properties of fermented wheat germ and garlic bulbs extract on Trypanosoma brucei-infected rats. J Med Plants Res. 4(19):2016-20.
Journal of Microbiology and Biotechnology
Kim M-H, Jo S-H, Ha K-S, Song J-H, Jang H-D, Kwon Y-I (2010): Antimicrobial activities of 1,4-benzoquinones and wheat germ extract. J Microbiol Biotechnol. 20:1204-09.
Journal of New Sciences, Agriculture and Biotechnology
Jribi S, Chabbouh M, Sassi K, Sfayhi D, Marzougut S, Amara H, Debbabi H (2018): La germination, un bioprocédé au service de l’industrie agro-alimentaire? Journal of New Sciences, Agriculture and Biotechnology. 57(5): 3725-37.
Journal of Nutrition & Food Sciences
Poudel R, Bhatta M (2016): Review of nutraceuticals and functional properties of whole wheat. J Nutr Food Sci. 6: 571. (6 pages). doi:10.4172/2155-9600.1000571
Journal of Orthomolecular Medicine
Schachter MB (2010): Integrative oncology for clinicians and cancer patients. J Orthomol Med. 25(4):169-94.
Journal of Pediatric Hematology/Oncology
Garami M, Schuler D, Babosa M, Borgulya G, Hauser P, Müller J, Paksy A, Szabó E, Hidvégi M, Fekete G (2004): Fermented wheat germ extract reduces chemotherapy-induced febrile neutropenia in pediatric cancer patients. J Pediatr Hematol Oncol. 26(10):631-5.
Journal of Pharmacological Sciences
Xie X, Zu X, Laster K, Dong Z, Kim DJ (2021): 2,6-DMBQ suppresses cell proliferation and migration via inhibiting mTOR/AKT and p38 MAPK signaling pathways in NSCLC cells. J Pharmacol Sci. 145:279-288.
Journal of Physiological Anthropology
Selhub EM, Logan AC, Bested AC (2014): Fermented foods, microbiota, and mental health: ancient practice meets nutritional psychiatry. Journal of Physiological Anthropology. 33:2 (12 pages).
Journal of the International Society for Advanced Cytometry
Kocsis Z, Marcsek Z, Tompa A (2003): Chemopreventive role of Avemar in decreasing the cytotoxic effect of xenobiotics. Journal of the International Society for Advanced Cytometry.
Journal of the Korean Society for Applied Biological Chemistry
Yoo J-G, Kim D-H, Park E-H, Lee J-S, Kim S-Y, Kim M-D (2011): Nuruk, a traditional Korean fermentation starter, contains the bioactive compound 2,6-dimethoxy-1,4-benzoquinone (2,6-DMBQ). J Korean Soc Appl Biol Chem. 54(5):795-8.
Journal of Translational Medicine
Grimm M, Cetindis M, Lehmann M, Biegner T, Munz A, Teriete P, Kraut W, Reinert S (2014): Association of cancer metabolism-related proteins with oral carcinogenesis – indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma? J Translational Med. 12:208.
Konventionelle und komplementare Therapie
Pfeifer B (2006): Avemar. In: Pfeifer B, Preiß J, Unger C, eds. Onkologie integrativ. Elsevier, Urban and Fischer, Munchen, p. 226-9.
Lupus
Ehrenfeld M, Blank M, Shoenfeld Y, Hidvégi M (2001): Avemar (a new benzoquinone-containing natural product) administration interferes with the Th2 response in experimental SLE and promotes amelioration of the disease. Lupus. 10:622-7.
Magyar Állatorvosok Lapja
Tarcsai KR, Kapran I, Hidvégi M, Stercz B, Nagy K, Ongrádi J (2020): Fermentált búzacsíra-kivonat (Avemar) antivirális hatásának vizsgálata macska AIDS modellben. Magyar Állatorvosok Lapja. 142: 731-41.
Magyar Állatorvosok Lapja
Farkas E (2004): Áttekintés az Avemar onkológiában betöltött szerepéről. Magy Belorv Arch. 57:4-9.
MBSE
Abdelbaky MS (2012): Effect of raw and fermented wheat germ on oxidative and immune stress induced by carbon tetrachloride (CCl4) hepatic toxicity in rats. MBSE. 2012, 26, 617-640.
Medicatrix
Cascio S (2013): Germe de blé fermenté, miracle santé à travers les âges. Medicatrix, Embourg (Belgique).
Medicine. Sociology. Philosophy. Applied research
Olesova LD (2021): Perspectivity of a Biogenic Product – Juice from Wheat Sprouts in Prevention and Treatment of Diseases in the North. MEDICINE. SOCIOLOGY. PHILOSOPHY Applied Research. (2):20-24.
Medicus Universalis
Farkas E (2006): Fermentált búzacsíra kivonat (Avemar) alkalmazásának lehetőségei a családorvosi gyakorlatba. Medicus Universalis. 39(1):19-31. Available at: http://hidvegimate.hu/download.php?id=101
Mediterranean Journal of Nutrition and Metabolism
Sukkar SG, Cella F, Rovera GM, Nichelatti M, Ragni G, Chiavenna G, Giannoni A, Ronzani G, Ferrari C (2008): A multicentric prospective open trial on the quality of life and oxidative stress in patients affected by advanced head and neck cancer treated with a new benzoquinone-rich product derived from fermented wheat germ (Avemar). Mediterranean J Nutr Metab. 1:37-42.
Metabolites
Rahman M, Hasan MR (2015): Cancer metabolism and drug resistance. Metabolites. 5: 571-600.
Metabolomics
Boros LG (2005): Metabolic targeted therapy of cancer: current tracer technologies and future drug design strategies in the old metabolic network. Metabolomics. 1(1):11-15.
Microbial Cell Factories
Rizzello CG, Mueller T, Coda R, Reipsch F, Nionelli L, Curiel JA, Gobbetti M (2013): Synthesis of 2-methoxy benzoquinone and 2,6-dimethoxybenzoquinone by selected lactic acid bacteria during sourdough fermentation of wheat germ. Microbial Cell Factories. 12:105.
Mini-Reviews in Medicinal Chemistry
Harrigan GG, Brackett DJ, Boros LG (2005): Medicinal chemistry, metabolic profiling and drug target discovery: A role for metabolic profiling in reverse pharmacology and chemical genetics. Mini Rev Med Chem. 5(1):13-20.
Natural Health Dossier
Herring J (2012): Three proven ways to survive cancer (and chemotherapy). Natural Health Dossier. August issue 28. (10 pages).
Natural Society
Sarich C (2014): Avemar: Fermented Wheat Germ Kills All Types of Cancer Cells FAST. [online document]. Natural Society.
Nature Biotechnology
Cascante M, Boros LG, Comín-Anduix B, Atauri P de, Centelles JJ, Lee W-NP (2002): Metabolic control analysis in drug discovery and disease. Nat Biotechnol. 20:243-9.
Nőgyógyászati Onkológia
Telekes A, Hidvégi M (2000): Az Avemar hatásmechanizmusa – rákellenes hatások laboratóriumi állatokban és daganatos betegekben. Nőgyógyászati Onkológia. 5:188-9. Available at: http://hidvegimate.hu/download.php?id=9
Telekes A, Hidvégi M (2001): Az Avemar hatásmódja (3) – jelátviteli folyamatok és anyagcsere. Nőgyógyászati Onkológia. 6:144-5. Available at: http://hidvegimate.hu/download.php?id=10
Nichelatti M, Hidvégi M (2002): Experimental and clinical results with Avemar (a dried extract from fermented weath germ) in animal cancer models and in cancer patients. Nőgyógyászati Onkológia. 7:40-1.
Telekes A, Hidvégi M (2001): Az Avemar hatásmódja (3) – jelátviteli folyamatok és anyagcsere. Nőgyógyászati Onkológia. 6:144-5. Available at: http://hidvegimate.hu/download.php?id=10
Nichelatti M, Hidvégi M (2002): Experimental and clinical results with Avemar (a dried extract from fermented weath germ) in animal cancer models and in cancer patients. Nőgyógyászati Onkológia. 7:40-1.
Boros LG, Hidvégi M (2002): Az Avemar hatásmódja (4) – daganatok anyagcseréjének módosítása. Nőgyógyászati Onkológia. 7:239-41.
Nutrients
Jeong H-Y, Choi Y-S, Lee J-K, Lee B-J, Kim W-K, Kang H (2017): Anti-inflammatory activity of citric acid-treated wheat germ extract in lipopolysaccharide-stimulated macrophages. Nutrients. 2017, 9(7), 730. (12 pages).
Zhurakivska K, Troiano G, Caponio VCA, Dioguardi M, Arena C, Muzio LL (2018): The Effects of Adjuvant Fermented Wheat Germ Extract on Cancer Cell Lines: A Systematic Review. Nutrients. 10:1546.
Song Y, Jeong H-Y, Lee J-K, Choi Y-S, Kim D-O, Jang D, Park C-S, Maeng S, Kang H (2019): Enzyme treatment alters the anti-inflammatory activity of the water extract of wheat germ in vitro and in vivo. Nutrients. 2019 Oct; 11(10): 2490. (13 pages).
Di Napoli R, Balzano N, Mascolo A, Cimmino C, Vitiello A, Zovi A, Capuano A, Boccellino M (2023): What is the role of nutraceutical products in cancer patients? A systematic review of randomized clinical trials. Nutrients. 15: 3249.
Nutrition and Cancer
Telekes A, Hegedűs M, Chae C-H, Vékey K (2009): Avemar (Wheat germ extract) in Cancer Prevention and Treatment. Nutr Cancer. 61(6):891-9.
Yang M-D, Chang W-S, Tsai C-W, Wang M-F, Chan Y-C, Chan K-C, Lu M-C, Kao A-W, Hsu C-M, Bau D-T (2016): Inhibitory effects of AVEMAR on proliferation and metastasis of oral cancer cells. Nutr Cancer. 68(3): 473-80.
Weitzen R, Epstein N, Oberman B, Shevetz R, Hidvégi M, Berger R (2021): Fermented wheat germ extract (FWGE) as a treatment additive for castration-resistant prostate cancer: a pilot clinical trial. Nutr Cancer. 2021 Jul 21;1-9. doi:10.1080/01635581.2021.1952457
Nutrition Journal
Brambilla D, Mancuso C, Scuderi MR, Bosco P, Cantarella G, Lempereur L, Benedetto GD, Pezzino S, Bernardini R (2008): The role of antioxidant supplement in immune system, neoplastic, and neurodegenerative disorders: a point of view for an assessment of the risk/benefit profile. Nutr J. 7:29 (9 pages).
Mueller T, Voigt W (2011): Fermented wheat germ extract – nutritional supplement or anticancer drug? Nutr J. 10:89. (6 pages).
Oncology
Shibuya N, Inoue K-ich, Tanaka G, Akimoto K, Kubota K (2015): Augmented pentose phosphate pathway plays critical roles in colorectal carcinomas. Oncology. 88:309-19.
Oncology & Hematology Review
Ceccherini E, Rinaldini M, Bignardi B, Senesi S, Caloni V (2002): Considerazioni sulle terapie non convenzionali dei tumori e sulla possibile attività antitumorale di alcune sostanze naturali. Oncology & Hematology Review. 4(2):109-120.
Oncology Letters
Imir NG, Aydemir E, Şimşek E (2018): Mechanism of the anti-angiogenic effect of Avemar on tumor cells. Oncol Lett. 15(2):2673-2678.
Oncology Reports
Saiko P, Ozsvar-Kozma M, Graser G, Lackner A, Grusch M, Madlener S, Krupitza G, Jaeger W, Hidvégi M, Agarawal RP, Fritzer-Szekeres M, Szekeres T (2009): Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis. Oncol Rep. 21:787-91.
Oncotarget
Simabuco FM, Morale MG, Pavan ICB, Morelli AP, Silva FR, Tamura RE (2018): p53 and metabolism: from mechanism to therapeutics. Oncotarget. 2018, Vol. 9, (No. 34), pp: 23780-23823.
Orvosi Hetilap (Hungarian Medical Journal)
Szende B, Rásó E, Hidvégi M, Tömösközi-Farkas R, Paku S, Prónai L, Bocsi J, Lapis K (1998): Egy új, szubszituált benzokinon tartalmú antimetasztatikus készítmény. Orv Hetil. 139(48):2893-7.
Farkas E (2005): Szupportív kezelés fermentált búzacsíra-kivonattal colorectalis carcinomában. Orv Hetil. 146(37):1925-31.
Barabás J, Németh Z (2006): A Magyar Arc-, Állcsont- és Szájsebészeti Társaság állásfoglalása szájüregi daganatos betegek Avemarral történő szupportív kezelésének indokoltságáról. Orv Hetil. 147(35):1709-11.
Oxidative Medicine and Cellular Longevity
Pomothy JM, Pászti-Gere E, Barna RF, Prokoly D, Jerzsele Á (2020): The Impact of Fermented Wheat Germ Extract on Porcine Epithelial Cell Line Exposed to Deoxynivalenol and T- 2 Mycotoxins. Oxidative Medicine and Cellular Longevity. Vol. 2020, Article ID 3854247, 9 pages. doi:https://doi.org/10.1155/2020/3854247
Mackei M, Vörösházi J, Sebők C, Neogrády Z, Mátis G, Jerzsele Á (2020): Fermented wheat germ extract as a redox modulator: Alleviating endotoxin-triggered oxidative stress in primary cultured rat hepatocytes. Oxidative Medicine and Cellular Longevity. Vol. 2020, Article ID 3181202, 9 pages. doi:https://doi.org/10.1155/2020/3181202
Pancreas
Boros LG, Lapis K, Szende B, Tömösközi-Farkas R, Balogh Á, Boren J, Marin S, Cascante M, Hidvégi M (2001): Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells. Pancreas. 23(2):141–7.
Boros LG, Lee W-NP, Go VLW (2002): A metabolic hypothesis of cell growth and death in pancreatic cancer. Pancreas. 24(1):26-33.
Pathophysiology
Minamiyama Y, Takemura S, Yoshikawa T, Okada S (2003): Fermented grain products, production, properties and benefits to health. Pathophysiology. 9:221-7.
PHD Tudományos Napok 2012 (Semmelweis Egyetem)
Stercz B (2012): A fermentált búzacsíra kivonat (Avemar) antivirális hatásai macska AIDS-modellben. PHD Tudományos Napok 2012 (Semmelweis Egyetem).
Phytomedicine
Yoo A, Jang YJ, Ahn J, Jung CH, Ha TY (2021): 2,6-Dimethoxy-1,4-benzoquinone increases skeletal muscle mass and performance by regulating AKT/mTOR signaling and mitochondrial function. Phytomedicine. 91: 153658 (11 pages).
PLoS ONE
Barisone GA, O’Donnell RT, Ma Y, Abuhay MW, Lundeberg K, Gowda S, Tuscano JM (2018): A purified, fermented, extract of Triticum aestivum has lymphomacidal activity mediated via natural killer cell activation. PLoS ONE. 13(1).
Poultry Science
Stipkovits L, Lapis K, Hidvégi M, Kósa E, Glavits R, Resetár Á (2004): Testing the efficacy of fermented wheat germ extract against mycoplasma gallisepticum infection of chickens. Poultry Sci. 83:1844-8.
Preprint
Koltai T (2021): Where do we stand with fermented wheat grain extract for cancer treatment: lights and shadow? Preprint. August 2021. doi:10.13140/RG.2.2.25241.54887
Preventive Nutrition and Food Science
Park E, Kim HO, Kim G-N, Song J-H (2015): Anti-oxidant and anti-adipogenic effects of ethanol extracts from wheat germ and wheat germ fermented with Aspergillus oryzae. Prev. Nutr. Food Sci. 20(1):29-37.
Pulmono
Hidvégi M, Moldvay J, Lapis K, Ajkay Z (2003): Fermentált búzacsíra tartalmú készítmény alkalmazásakor javul a tüdőrákos betegek életminősége. Medicus Anonymus (Pulmono). 1:13-4.
Romanian Journal of Diabetes Nutrition and Metabolic Diseases
Mogoș T, Dondoi C, Chelan C, Iacobini AE (2015): A review of recommended foods in the prevention of cancer. Rom J Diabetes Nutr Metab Dis. 22(2):193-200.
Scientific Reports
Bencze G, Bencze S, Rivera KD, Watson JD, Hidvégi M, Orfi L, Tonks NK, Pappin DJ (2020): Mito‑oncology agent: fermented extract suppresses the Warburg effect, restores oxidative mitochondrial activity, and inhibits in vivo tumor growth. Sci Rep. 10: 14174. doi:10.1038/s41598-020-71118-3
Seminars in Cancer Biology
Baig MH, Adil M, Khan R, Dhadi S, Ahmad K, Rabbani G, Bashir T, Imran MA, Husain FM, Lee EJ, Kamal MA, Choi I (2019): Enzyme targeting strategies for prevention and treatment of cancer: Implications for cancer therapy. Semin Cancer Biol. 56: 1-11. doi:https://doi.org/10.1016/j.semcancer.2017.12.003
Stem Cell Research & Therapy
Abdelmonem M, Kassem SH, Gabr H, Shaheen AA, Aboushousha T (2015): Avemar and Echinacea extracts enhance mobilization and homing of CD34+ stem cells in rats with acute myocardial infarction. Stem Cell Research & Therapy. 6:172 (17 pages).
Support Care Cancer
Radossi AL, Taromina K, Marjerrison S, Diorio CJ, Similio R, Njuguna F, Afungchwi GM, Ladas EJ (2017): A systematic review of integrative clinical trials for supportive care in pediatric oncology: a report from the International Society of Pediatric Oncology, T&CM collaborative. Support Care Cancer. (17 pages). doi:10.1007/s00520-017-3908-0
Synthesis
Editorial (2008): In pursuit of options. Norman deLeuze fuels the hunt for a nontoxic cure for lymphoma. Synthesis. (University of California Davis Cancer Center). 11(1):19-21.
The Journal of Biological Chemistry
Comín-Anduix B, Boros LG, Marin S, Boren J, Callol-Massot C, Centelles JJ, Torres JL, Agell N, Bassilian S, Cascante M (2002): Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells. J Biol Chem. 277(48):46408-14.
The Korea Journal of Herbology
Lee C, Park G-H, Lee J-W, Jang J-H (2015): Protective effect of wheat bran extract against β-amyloid-induced cell death and memory impairment. The Korea Journal of Herbology. 30(1): 67-75.
Townsend Letter
Kenner D (2006): Avemar – a functional food with proven anti-cancer effect. Townsend Letter. August/September issue:96-100.
Wilson D (2007): Anti-aging and anti-cancer properties of Avemar. Townsend Letter. October issue:101-4.
Traub M (2010): Avemar outshines new cancer ‘breakthrough’ drug. Townsend Letter. 2010 October issue.
Transactions of the CSAE
Bin X, Ying D (2011): Present situation and trends of wheat germ industrialization developing. Transactions of the CSAE. 27(S2):341-5. (in Chinese with English abstract).
Translational Research in Urology
Mirzaei A, Khatami F, Ebrahimi M, Mousavibahar SH, Narouie B (2019): The Effect of Herbal Extracts on the Treatment and Prevention of Prostate Cancer: A Literature Review. Translational Research in Urology. 1(2):67-73 Autumn 2019.
UCLA School of Medicine
Boros LG (2005): Metabolic profile of inflammatory breast cancer: aiding diagnosis and treatment. UCLA School of Medicine.
Veterinary Medicine and Science
Tarcsai KR, Hidvégi M, Corolciuc O, Nagy K, Abbas AA, Ablashi DV, Kövesdi V, Ongrádi J (2023): The effects of Avemar treatment on feline immunodeficiency virus infected cell cultures. Vet Med Sci. 9: 1446-1455.
World Cancer Research Journal
De Monaco A, D’Orta A, Del Buono A (2014): Evolution of bread-making quality in wheat: implications about cancer prevention. World Cancer Res J. 1(2): e214.
World Journal of Diabetes
Mirmiran P, Bahadoran Z, Azizi F (2014): Functional foods-based diet as a novel dietary approach for management of type 2 diabetes and its complications: A review. World J Diabetes. 5(3): 267-81.
World Journal of Pharmaceutical Research
Waasiullah M, Yadav P, Yadav S, Mishra P (2023): Role of nutraceutical and herbal adjuvant in the chemotherapy of cancer. World J Pharm Res. 12, 874-887.